Author: Thibaut, A. – The management of patients with severe brain injuries and prolonged disorders of consciousness raises important issues particularly with respect to their therapeutic options. The scarcity of treatment options is challenged by new clinical and neuroimaging data indicating that some patients with prolonged disorders of consciousness might benefit from therapeutic interventions, even […]

Authors: Rosanova, M., Fecchio, M., Casarotto, S., Sarasso, S., Casali, A.G., Pigorini, A., Comanducci, A., Seregni, F., Devalle, G., Citerio, G., Bodart, O., Boly, M., Gosseries, O., Laureys, S., Massimini, M. – Unresponsive wakefulness syndrome (UWS) patients may retain intact portions of the thalamocortical system that are spontaneously active and reactive to sensory stimuli but fail […]

Authors: Fecchio, M., Pigorini, A., Comanducci, A., Sarasso, S., Casarotto, S., Premoli, I., Derchi, C.-C., Mazza, A., Russo, S., Resta, F., Ferrarelli, F., Mariotti, M., Ziemann, U., Massimini, M., Rosanova, M. – Transcranial magnetic stimulation (TMS) of the primary motor cortex (M1) can excite both cortico-cortical and cortico-spinal axons resulting in TMS-evoked potentials (TEPs) and […]

Authors: Colombo, M.A., Napolitani, M., Boly, M., Gosseries, O., Casarotto, S., Rosanova, M., Brichant, J.-F., Boveroux, P., Rex, S., Laureys, S., Massimini, M., Chieregato, A., Sarasso, S. – Despite the absence of responsiveness during anesthesia, conscious experience may persist. However, reliable, easily acquirable and interpretable neurophysiological markers of the presence of consciousness in unresponsive states […]

Authors: Bayne, T., Seth, A.K., Massimini, M. – Ordinary human experience is embedded in a web of causal relations that link the brain to the body and the wider environment. However, there might be conditions in which brain activity supports consciousness even when that activity is fully causally isolated from the body and its environment. […]

Authors: Rizkallah J., Annen, J., Modolo J., Gosseries O., Benquet P., Mortaheb S., Amoud H., Cassol H., Mheich A., Thibaut A., Chatelle C., Hassan M. – Increasing evidence links disorders of consciousness (DOC) with disruptions in functional connectivity between distant brain areas. However, to which extent the balance of brain network segregation and integration is modified in DOC […]

Authors: Bensaid S., Modolo J., Merlet I., Wendling F., Benquet P. – Understanding the origin of the main physiological processes involved in consciousness is a major challenge of contemporary neuroscience, with crucial implications for the study of Disorders of Consciousness (DOC). The difficulties in achieving this task include the considerable quantity of experimental data in […]

Authors: Modolo J., Hassan M., Wendling F., Benquet P. – Identifying the physiological processes underlying the emergence and maintenance of consciousness is one of the most fundamental problems of neuroscience, with implications ranging from fundamental neuroscience to the treatment of patients with disorders of consciousness (DOCs). One major challenge is to understand how cortical circuits […]

Authors: – Sleigh J, Pullon RM, Vlisides PE, Warnaby CE. BACKGROUND: Previous work on the electroencephalographic (EEG) effects of anaesthetic doses of ketamine has identified a characteristic signature of increased high frequency (beta-gamma) and theta waves alternating with episodic slow waves. It is unclear which EEG parameter is optimal for pharmacokinetic-pharmacodynamic modelling of the hypnotic […]

Authors: Moser J, Bensaid S, Kroupi E, Schleger F, Wendling F, Ruffini G, Preißl H. – In this work, we aim to investigate whether information based metrics of neural activity are a useful tool for the quantification of consciousness before and shortly after birth. Neural activity is measured using fetal magnetoencephalography (fMEG) in human fetuses and neonates. Based on […]